B6-huOX40/huOX40L Mouse
Product Name
B6-huOX40/huOX40L Mouse
Product ID
C001936
Strain Name
C57BL/6NCya-Tnfsf4tm1(hTNFSF4)Tnfrsf4tm1(hTNFRSF4)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-huOX40/huOX40L Mouse (Catalog C001936) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Alias
GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, TNLG2B, OX40, ACT35, CD134, IMD16, TXGP1L
Chromosome
Chr 1, Chr 1
MGI ID
Datasheet
Strain Description
The B6-huOX40/huOX40L mouse is a dual-gene humanized model obtained by mating B6-huOX40L (huTNFSF4) mice (catalog No.: C001719) with B6-huOX40 (huTNFRSF4) mice (catalog No.: C001805). This model can be used for the research of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), as well as tumor immunity. It is also applicable to the screening and development of TNFSF4/TNFRSF4-targeted drugs, and the pre-clinical evaluation of their efficacy and safety.
Strain Strategy
Figure 1. Gene editing strategy of B6-huOX40L (huTNFSF4) mice. The mouse Tnfsf4 endogenous extracellular domain was replaced with the human TNFSF4 extracellular domain.
Figure 2. Gene editing strategy of B6-huOX40 (huTNFRSF4) mice. The mouse Tnfrsf4 endogenous extracellular domain was replaced with the human TNFRSF4 extracellular domain. The murine signal peptide was preserved.
Application Area
Screening, development, and pre-clinical evaluation of TNFSF4/TNFRSF4-targeted drugs;
Research on the pathological mechanisms and treatment methods of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA);
Research on tumor immunology;
Research on immunodeficiency type 16.
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.