huC3/huC5 Mouse
Product Name
huC3/huC5 Mouse
Product ID
C002009
Strain Name
C57BL/6JCya-C3tm1(hC3)Hctm1(hC5)/Cya
Backgroud
C57BL/6JCya
Status
When using this mouse strain in a publication, please cite “huC3/huC5 Mouse (Catalog C002009) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Alias
ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, C5D, C5a, C5b, ECLZB, CPAMD4
Chromosome
Chr 19, Chr 9
Datasheet
Strain Description
Strain Strategy
The huC3/huC5 mice are a dual-gene humanized model obtained by mating huC3 mice (catalog No.: C001955) with huC5 mice (catalog No.: C001824).
Figure 1. Gene editing strategy of huC3 mice. The sequences from upstream of exon 1 to the TGA stop codon of mouse C3 were replaced with the sequences from upstream of exon 1 to downstream of exon 41 of human C3.
Figure 2. Gene editing strategy of huC5 mice. The exon 2~41 and flanking sequences of mouse Hc were replaced with the exon 2~41 and flanking sequences of human C5. The murine exon 1 coding region, containing signal peptide, was kept.
Application Area
Development, screening, and preclinical pharmacological and efficacy evaluation of C3/C5-targeted drugs;
Research on ophthalmic diseases, such as age-related macular degeneration (AMD);
Research on autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and vasculitis;
Research on kidney diseases, such as immune complex glomerulonephritis, hemolytic uremic syndrome, lupus nephritis, membranous nephritis, and immune nephropathy.
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