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Animal Models
C57BL/6JCya-Yipf5em1/Cya
Yipf5 is located on chromosome 18 of mice. Nuclease Technology will be used to design sgRNA; Yipf5 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yipf3em1/Cya
Yipf3 is located on chromosome 17 of mice. Nuclease Technology will be used to design sgRNA; Yipf3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Comtem1/Cya
Comt is located on chromosome 16 of mice. Nuclease Technology will be used to design sgRNA; Comt knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6NCya-Compem1/Cya
Comp is located on chromosome 8 of mice. Nuclease Technology was used to design sgRNA; Comp knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yipf6em1/Cya
Yipf6 is located on chromosome X of mice. Nuclease Technology will be used to design sgRNA; Yipf6 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yif1bem1/Cya
Yif1b is located on chromosome 7 of mice. Nuclease Technology will be used to design sgRNA; Yif1b knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yipf7em1/Cya
Yipf7 is located on chromosome 5 of mice. Nuclease Technology will be used to design sgRNA; Yipf7 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yif1aem1/Cya
Yif1a is located on chromosome 19 of mice. Nuclease Technology will be used to design sgRNA; Yif1a knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yipf4em1/Cya
Yipf4 is located on chromosome 17 of mice. Nuclease Technology will be used to design sgRNA; Yipf4 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Yipf1em1/Cya
Yipf1 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Yipf1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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