In recent years, significant progress has been made in understanding the genetic factors underlying various ophthalmic diseases. The development of relevant animal models has played a crucial role in advancing preclinical research, including the study of disease mechanisms, drug target identification, and evaluation of treatment efficacy.
Cyagen has created a series of gene-edited models for ophthalmic diseases, such as Leber Congenital Amaurosis 2 (LCA2), Leber Congenital Amaurosis 10 (LCA10), retinitis pigmentosa, retinal degeneration, age-related macular degeneration, and corneal endothelial dysfunction. These models exhibit well-defined phenotypic characteristics and offer stable and heritable genetic traits, making them valuable tools for various ophthalmology-related investigations.
Additionally, Cyagen provides a specialized platform for ophthalmic pharmacology analysis. This comprehensive service covers ocular drug administration, in vivo ocular detection, ocular tissue collection, histological analysis, and gene and protein expression detection, ensuring integrate evaluation of ophthalmic drug efficacy.
Validated Genetic Ophthalmic Disease Models
| Product ID | Product Name | Related Diseases | Targeting Type |
|---|---|---|---|
| C001277 | Pde6b-MU1 | Retinitis pigmentosa (RP) | Mu |
| C001276 | Pde6b-MU2 | Retinitis pigmentosa (RP) | Mu |
| C001396 | B6J-hRho | Retinitis Pigmentosa (RP) | Humanization |
| C001384 | Pde6b KO | Retinitis Pigmentosa (RP), Congenital Stationary Night Blindness (CSNB) | KO |
| C001425 | Nr2e3 KO | Enhanced S Cone syndrome, ESCS; Retinitis pigmentosa, RP | KO |
| C001385 | Prph2 KO | Retinitis Pigmentosa (RP), Age-related Macular Degeneration (AMD), Macular Dystrophy (MDs) | KO |
| C001555 | B6-hVEGFA | Age-related macular degeneration (AMD) | Humanization |
| C001395 | hVEGFA-TG | Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR) | Humanization(TG) |
| C001386 | Tub-KO | Retinal Degeneration (RD) | KO |
| C001387 | Rpe65 KO | Retinal Degeneration (RD), Leber Congenital Amaurosis 2 (LCA2) | KO |
| C001360 | B6-Rpe65 R44X | Leber Congenital Amaurosis 2 (LCA2) | Mu |
| I001217 | B6-hCEP290 | Leber Congenital Amaurosis Type 10（LCA10） | Humanization |
| C001551 | B6-hABCA4 | Stargardt disease | Humanization |
| C001554 | B6-hUSH2A(E10-15) | Usher syndrome type 2 | Humanization |
| C001546 | B6-hTGFBI | corneal dystrophy (CD) | Humanization |
| I001134 | Abca4 KO | Stargardt Disease (STGD), Cone-rod Dystrophy (CRD), and Retinitis Pigmentosa (RP) | KO |
| C001700 | Rho KO | Retinitis Pigmentosa (RP), congenital stationary night blindness (CSNB) | KO |