B6-hRHO*P23H/hRHO
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Basic Information
Model Name
B6-hRHO*P23H/hRHO
Product ID
C001517
Gene Name
Background
C57BL/6JCya
Gene Alias
RP4; OPN2; CSNBAD1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
3
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Note: When using this mouse strain in a publication, please cite “B6-hRHO*P23H/hRHO mice (Catalog C001517) were purchased from Cyagen.”
Strain Description
This strain is a humanized model of the Rho gene with a heterozygous P23H mutation. It is obtained by mating homozygous B6J-hRHO mice (Catalog Number: C001396) with homozygous B6-hRHO-P23H mice (Catalog Number: C001495). In this model, the mouse Rho gene is replaced by the human RHO gene carrying the pathogenic mutation (P23H) and the human RHO gene without the mutation, respectively. The abnormal protein encoded by the mutant human gene is expressed in the mice. Therefore, the model exhibits abnormalities in the appearance and function of the retina, as well as visual defects.
Application Area
Research on retinitis pigmentosa (RP)
Research on congenital stationary night blindness (CSNB)
Research on other retinal diseases
Validation Data