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B6-huTFRC
Product ID:
C001860
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
B6-huTFRC
Product ID
C001860
Gene Name
TFRC
Background
C57BL/6NCya
Gene Alias
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
Classification
Full-Gene Humanized Models
NCBI ID
7037
Phenotype
MGI:98822
Chromosome
--
More
Rare Disease Data Center >>
Datasheet
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Note
Note: When using this mouse strain in a publication, please cite “B6-huTFRC mice (Catalog C001860) were purchased from Cyagen.”
Strain Description
B6-huTFRC mouse model was generated by replacing the mouse Tfrc endogenous extracellular domain (aa.89~763) with the human TFRC extracellular domain (aa.89~760). The murine cytoplasmic and helical (aa.1~88) will be kept. This model is valuable for studying iron metabolism disorders, neurodegenerative diseases, and tumor development, supporting the development of TFR1-targeted therapeutics and preclinical pharmacological evaluations.
Application Area
Area
Studies on iron metabolism disorders, neurodegenerative diseases, and tumor development
Area
Development, screening, and evaluation of TFRC-targeted therapies
Area
Research and evaluation of drug delivery across the blood-brain barrier (BBB)
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