B6-huOSM/hOSMR Mouse
Product Name
B6-huOSM/hOSMR Mouse
Product ID
C001901
Strain Name
C57BL/6NCya-Osmtm1(hOSM)Osmrtm1(hOSMR)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-huOSM/hOSMR Mouse (Catalog C001901) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Alias
OSMRB, PLCA1, IL-31RB, OSMRbeta, IL-31R-beta
Chromosome
Chr 22, Chr 5
MGI ID
Datasheet
Strain Description
The B6-huOSM/hOSMR mouse is a dual-gene humanized model obtained by crossing B6-huOSM mice (catalog No.: C001815) with B6-hOSMR mice (catalog No.: C001841). This model can be used for studying the pathogenesis of inflammatory diseases (such as rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, and pancreatic cancer), pulmonary and skin diseases (such as asthma and psoriasis), cardiovascular diseases (such as atherosclerosis), liver diseases (such as fibrosis), and hematopoietic system and bone marrow-related diseases, as well as for the development of OSM/OSMR-targeted drugs.
Strain Strategy
Figure 1. Gene editing strategy of B6-huOSM Mice. The sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Osm gene will be replaced with the sequences from the ATG start codon to the TAG stop codon of the human OSM gene.
Figure 2. Gene editing strategy of B6-hOSMR mice. The coding sequences of exon 2 plus partial intron 2 of mouse Osmr will be replaced with the Kozak-OSMR chimeric CDS-3'UTR of mouse Osmr-WPRE-BGH pA cassette.
OSMR chimeric CDS: Signal Peptide and Extracellular Domain of Human OSMR + Transmembrane and Cytoplasmic Domain of Mouse Osmr.
Application Area
Screening, development, and safety evaluation of OSM/OSMR-targeted drugs;
Research on inflammatory diseases (such as rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, asthma, and psoriasis);
Research on cancers (cervical squamous cell carcinoma, lung adenocarcinoma, pancreatic cancer);
Research on cardiovascular diseases (such as atherosclerosis) and liver diseases (such as fibrosis);
Research on the hematopoietic system and bone marrow-related diseases.
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