huTFRC/huTNF(B6;D1) Mouse
Product Name
huTFRC/huTNF(B6;D1) Mouse
Product ID
C002011
Strain Name
C57BL/6N;DBA/1Cya-Tfrctm2(hTFRC)Tnfem1(hTNF)/Cya
Backgroud
C57BL/6N;DBA/1Cya
Status
When using this mouse strain in a publication, please cite “huTFRC/huTNF(B6;D1) Mouse (Catalog C002011) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
TFRC & TNF
Gene Alias
T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46, DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha
NCBI ID
Chromosome
Chr 3 (Human), Chr 6 (Human)
MGI ID
Datasheet
Strain Description
The huTFRC/huTNF(B6;D1) mice are a dual-gene humanized model obtained by mating huTFRC mice (Catalog No.: C001860) with huTNF(DBA/1) mice (Catalog No.: C001587). This model can be used for the research of neurodegenerative diseases, immune-related diseases such as rheumatoid arthritis (RA), and the occurrence and development of tumors, as well as preclinical studies of TFRC/TNF-targeted drugs.
Strain Strategy
The huTFRC/huTNF(B6;D1) mice are a dual-gene humanized model obtained by mating huTFRC mice (Catalog No.: C001860) with huTNF(DBA/1) mice (Catalog No.: C001587).
Figure 1. Gene editing strategy of huTFRC mice. The mouse Tfrc endogenous extracellular domain was replaced with the human TFRC extracellular domain. The murine cytoplasmic and helical regions were kept.
Figure 2. Gene editing strategy of huTNF(DBA/1) mice. The mouse Tnf genome plus flanking sequence was replaced with the human TNF genome plus flanking sequence.
Application Area
Screening, development, and preclinical evaluation of TFRC/TNF-targeted drugs;
Research on neurodegenerative diseases;
Research on drug delivery across the blood-brain barrier (BBB);
Research on immune-related diseases such as rheumatoid arthritis (RA);
Research on tumorigenesis.
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