hCRBN/hutau-P301S Mouse
Product Name
hCRBN/hutau-P301S Mouse
Product ID
C002086
Strain Name
C57BL/6JCya-Crbnem1(hCRBN)Mapttm3(hMAPT*P301S)/Cya
Backgroud
C57BL/6JCya
Status
When using this mouse strain in a publication, please cite “hCRBN/hutau-P301S Mouse (Catalog C002086) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
MAPT & CRBN
Gene Alias
TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, tau-40, FTDP-17, PPP1R103, Tau-PHF6, MRT2, MRT2A
NCBI ID
Chromosome
Chr 17 (Human), Chr 3 (Human)
MGI ID
Datasheet
Strain Description
The hCRBN/hutau-P301S mouse is a dual-gene humanized model obtained by crossing the hCRBN mouse (Catalog No.: C001683) with the hutau-P301S mouse (Catalog No.: C001836). The hCRBN/hutau-P301S mouse is a dual-target humanized model that integrates targeted protein degradation (TPD) technology with research on tau-related neurodegenerative diseases. It can be used to evaluate CRBN-based targeted protein degradation (TPD) therapeutics, including molecular glues and proteolysis-targeting chimeras (PROTACs), for the treatment of tauopathies. This model serves as an ideal preclinical research platform for developing innovative therapies for frontotemporal dementia (FTD), Alzheimer's disease (AD), and other tau-related neurodegenerative diseases.
Strain Strategy
The hCRBN/hutau-P301S mouse is a dual-gene humanized model obtained by crossing the hCRBN mouse (Catalog No.: C001683) with the hutau-P301S mouse (Catalog No.: C001836).
Figure 1. Gene editing strategy of hCRBN mice. The exon 2 to partial intron 2 of mouse Crbn was replaced with Exon 2~11 of Human CRBN CDS-BGH pA cassette.
Figure 2. Gene editing strategy of hutau-P301S mice. The mouse Mapt gene was replaced with the human MAPT gene carrying the P301S mutation.
Application Area
Research on CRBN-based targeted protein degradation (TPD), including molecular glues and proteolysis-targeting chimeras (PROTACs), for tauopathies;
Development of innovative therapies for frontotemporal dementia (FTD), Alzheimer's disease (AD) and other tau-related neurodegenerative diseases.
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