FVB-hHTT Q150 KI
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Strain Description
This strain is an hHTT Q150 knock-in mouse model generated by gene editing technology, in which a mutated human HTT gene sequence carrying 150 CAG repeats is inserted into the mouse genome. Literature reports have shown that these mice exhibit pathological features and functional impairments characteristic of Huntington's disease, and are suitable for developing and screening therapeutic drugs for Huntington's disease and safety evaluation. The heterozygous FVB-hHTT Q150 KI mice are viable and fertile.
Application Area
Development and screening of therapeutic drugs for Huntington's disease
Evaluation of therapeutic drug efficacy and safety for Huntington's disease
Research on the pathogenesis of Huntington's disease
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