B6-hPCSK9/Apoe KO
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hPCSK9/Apoe KO
Product ID
I001220
Background
C57BL/6Cya
Gene Alias
FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; Apo-E
Classification
Tumor Target Humanized Models,Metabolic Target Humanized Models,Cytokine Humanized Models,Metabolic Disease Models,Autoimmune Disease Models
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hPCSK9/Apoe KO mice (Catalog I001220) were purchased from Cyagen.”
Strain Description
The B6-hPCSK9/Apoe KO mice are obtained by crossing B6-hPCSK9 mice with B6J-Apoe KO mice. The B6-hPCSK9/Apoe KO mice, while expressing the human PCSK9 protein, exhibit significantly elevated cholesterol levels and spontaneous atherosclerosis characteristics. These mice provide an ideal platform for the PCSK9-targeted drug development in hyperlipidemia and cardiovascular diseases, demonstrating good clinical and pathological relevance.
Application Area
Development, screening, and preclinical evaluation of PCSK9-targeted drugs
Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
Validation Data