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B6-hPCSK9/Apoe KO
Product ID:
I001220
Background:
C57BL/6Cya
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Strain Description
The B6-hPCSK9/Apoe KO mice are obtained by crossing B6-hPCSK9 mice with B6J-Apoe KO mice. The B6-hPCSK9/Apoe KO mice, while expressing the human PCSK9 protein, exhibit significantly elevated cholesterol levels and spontaneous atherosclerosis characteristics. These mice provide an ideal platform for the PCSK9-targeted drug development in hyperlipidemia and cardiovascular diseases, demonstrating good clinical and pathological relevance.
Application Area
Area
Development, screening, and preclinical evaluation of PCSK9-targeted drugs
Area
Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
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