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Custom Models
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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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Testimonials
"I've been very happy with Cyagen's service so I've been referring a lot of colleagues... thanks for
the
great service."
'- Washington University in St. Louis
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Citations
IMMUNITY 47:107 (2017) IF=22.845
Leading Mouse Models for Research
Metabolism, Neuroscience, Immunology, Oncology, m6A Methylation Modification and Related Diseases
In just over two years since launching Cyagen Knockout Catalog Models, it has accelerated research progress for over 2000+ research groups and helped 300+ companies in the race against time for therapeutic drug development. We have statistically analyzed more than ten top-selling knockout mouse strains, which cover five research fields: metabolic disease, neuroscience, immunity and inflammation, oncology, m6A methylation modification and related diseases, so as to facilitate users’ to understanding of the most frequently used models from our repository.
| Research Fields | Gene | Strain Background | Modification Type | Item No. | Status |
|---|---|---|---|---|---|
| Metabolic Disease | Fgf21 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21687-Fgf21 | Live, Sperm cryopreservation |
| Sirt3 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-22145-Sirt3 | Live, Sperm cryopreservation | |
| Sirt5 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-00451-Sirt5 | Live, Sperm cryopreservation | |
| Neuroscience: Parkinson's Disease, Alzheimer's Disease etc. | Nfe2l2 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21018-Nfe2l2 | Live, Sperm cryopreservation |
| Trem2 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-23056-Trem2 | Live, Sperm cryopreservation | |
| Immunity and Inflammation | Ifnar1 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21032-Ifnar1 | Live, Sperm cryopreservation |
| Il17a | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21005-Il17a | Live, Sperm cryopreservation | |
| Oncology | Nfe2l2 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21018-Nfe2l2 | Live, Sperm cryopreservation |
| Sirt3 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-22145-Sirt3 | Live, Sperm cryopreservation | |
| Ifnar1 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21032-Ifnar1 | Live, Sperm cryopreservation | |
| Ythdf3 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-06061-Ythdf3 | Live, Sperm cryopreservation | |
| Ythdf1 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-11432-Ythdf1 | Live, Sperm cryopreservation | |
| Il17a | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-21005-Il17a | Live, Sperm cryopreservation | |
| M6A Methylation Modification and Related Diseases | Ythdf1 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-11432-Ythdf1 | Live, Sperm cryopreservation |
| Ythdf3 | C57BL/6N | CRISPR-Pro Knockout (KO) | KOCMP-06061-Ythdf3 | Live, Sperm cryopreservation |
Applications for KO MiceStudies of gene function
Absence of gene activity can elucidate the biological roles of a gene and its potential participation in pathogenesis of human disease. Providing in vivo data on the mechanism of action (MOA) can improve the significance of your publications and even expedite results.
Target discovery and confirmation
Data from in vitro experiments are not reliable enough on their own; in vivo data is required to validate the target for a successful drug development program.
Verifying compound specificity
The primary cause of drug failures is attributed to non-specificity, which may cause dangerous off-target effects. KO models can remove a functional protein target, providing an in vivo system to detect potential off-target effects of an antagonist.
