Humanized Target Gene Disease Models

In the realm of biomedical research and the pursuit of innovative clinical treatment strategies, Humanized Genetic Models stand at the forefront, offering a unique window into the intricacies of human biology. By strategically replacing one or more genes with their human counterparts, these models can express complete human proteins or chimeric proteins featuring human-specific structural domains. This revolutionary approach allows researchers to simulate the nuanced processes of human drug action with unprecedented accuracy in the preclinical research environment.

The application of genetically humanized mice spans a wide array of critical areas in biomedical research and clinical development. Notably, these models play a pivotal role in tumor immunotherapy, offering a dynamic platform for assessing CAR-T cell toxicity, testing and validating various immunotherapy approaches, exploring combination immunotherapy strategies, and identifying elusive hematologic disorder targets such as leukemia stem cells and leukemia-initiating cells.

The Cyagen Screening and Evaluation Mouse Model Platform is a trailblazing initiative that provides a diverse range of target gene humanization models to support new drug development, including hF11, B6-hCD47, B6-hPDL1-V, hCTLA4, B6-hIGHG1, and more. To inquire about the development of any genetically humanized mouse model of disease, please contact us – we can create custom genetic humanization models to support your preclinical research and drug discovery.

Below, we present a comprehensive table detailing specific Humanized Target Gene Disease Models offered by the Cyagen Screening and Evaluation Mouse Model Platform. These models, exemplified by strains like B6-hCD47, B6-hPDL1-V, hCTLA4, and more, serve as indispensable tools for researchers navigating the frontier of biomedical innovation. Each product is meticulously designed to contribute to the understanding of diverse diseases, ranging from hematologic disorders to metabolic diseases, and to facilitate the development and validation of novel therapeutic interventions. Click on the corresponding product name to view mouse details and validation data.