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Research Trends
Unveiling the Secrets of the DIO-B6-M Mouse Model for Obesity Research
Sep 13, 2024
Obesity has become a global health issue. According to statistics, 2.5 billion adults were classified as overweight in 2022, with over 890 million suffering from obesity. Read More >
Research Trends
How to Culture & Edit NCI-H358 Cells: Best Practices for KRAS G12C Mutation Research
Sep 05, 2024
Lung cancer researchers often utilize the NCI-H358 cell line for its KRAS G12C mutation to test inhibitors specifically targeting this mutation, as well as explore potential combination therapy strategies. Read More >
Research Trends
Research Notes: How to Perform Successful Gene Editing & Cell Culturing with SH-SY5Y Cells
Aug 23, 2024
The SH-SY5Y cell line is one of the most widely used cell models for studying neurodegenerative diseases. In this post, we provide details on how to utilize the SH-SY5Y cell line for research purposes, including protocols for successful gene editing and cell culture. Read More >
Research Trends
Adipoq-iCre Mice for Conditional Gene Targeting of Adipose Tissues & Fluorescent Detection Data
Aug 02, 2024
In the realm of scientific research, particularly in studies focusing on fat cells and metabolic diseases, accurate and efficient fluorescent detection is essential. Read More >
Research Trends
Improving Pancreas-Specific Cre Mouse Lines with the Pdx1-CreERT2 Mouse Model
Jul 29, 2024
The Cre-Lox system allows for gene knockout/knockin in specific cells/tissues, with the timing of its expression is determined by the promoter. Read More >
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Humanized Immune System Mice: An Effective Preclinical Model for Reproducing Human Immune-Tumor Interactions
Jul 19, 2024
Humanized Immune System Mice (HIS mice) are developed by transplanting human immune system components into mice, resulting in animal models that partially or fully replicate human immune system functions. Read More >
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Highly Efficient Human NK Cell Immune Reconstitution Mouse Models: NKG-hIL15 & huHSC-NKG-hIL15 Mice
Jul 12, 2024
Immunotherapy works by mobilizing immune cells within the body to enhance the immune system's ability to recognize, kill, and eliminate tumor cells. Given the differences between the immune systems of mice and humans, immunotherapies are typically evaluated in preclinical studies using humanized immune system (HIS) mouse models. Read More >
Research Trends
Hope for "Butterfly Children"—New Models in Research on Dystrophic Epidermolysis Bullosa (DEB)
Jul 05, 2024
In everyday life, hugging is a way for people to express love and kindness. However, for individuals with Epidermolysis Bullosa (EB), this simple act of intimacy can cause immense pain. Read More >
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HFD+CCl4-Induced Metabolic Dysfunction-Associated Steatohepatitis (MASH/NASH) Mice
Jun 28, 2024
Metabolic dysfunction-associated steatohepatitis (MASH), previously referred to as nonalcoholic steatohepatitis (NASH), is a chronic liver disease. This condition frequently arises from metabolic irregularities like obesity or diabetes, leading to an accumulation of fat in the liver, which can become toxic and cause inflammation. Read More >
Research Trends
Recommended Model | Fabry Disease (FD) Research Model - Gla-KO Mice
Jun 21, 2024
Fabry Disease (FD) is a rare genetic disorder categorized as a lysosomal storage disease (LSD). It is caused by a deficiency in the activity of the lysosomal enzyme alpha-galactosidase A (α-GalA), leading to the accumulation of its metabolic substrate, Read More >