Most Popular
Weekly Gene
The Culprits of Amyotrophic Lateral Sclerosis (ALS)
Aug 09, 2022
Age and heredity are currently recognized as the most relevant causative factors for amyotrophic lateral sclerosis (ALS), although age is also the biggest risk factor for many other neurodegenerative diseases. While inherited ALS accounts for only 5% of patients, there are more than 20 gene mutations identified as the pathological culprits of ALS. Read More >
Weekly Gene
Genetic Factors of Eye Disease: Retinitis Pigmentosa (RP) & the RHO Gene
May 23, 2022
Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous blinding retinal disease, which belongs to the large group of inherited retinal degenerations —for which 54 retinal genes have been found to be mutated thus far. Read More >
Weekly Gene
SYNGAP1-Related Intellectual Disability (MRD5)
Apr 20, 2022
SYNGAP1 (Synaptic Ras GTPase Activating Protein 1) is a Protein Coding gene. The SYNGAP1 gene is located on Chromosome 6 and is responsible for producing the SynGAP protein. Read More >
Weekly Gene
Rare Diseases Caused by the CEP290 Gene
Mar 25, 2022
CEP290 (Centrosomal Protein 290) is a Protein Coding gene, encodes a centrosomal protein involved in ciliary assembly and ciliary trafficking. Read More >
Weekly Gene
Targeting BBS5 in Bardet-Biedl syndrome (BBS)
Feb 16, 2022
Bardet-Biedl Syndrome (BBS) is a rare genetic disorder with highly variable symptoms which may include retinal degeneration. Read More >
Weekly Gene
[Weekly Gene] The Secret of YBX2's Regulatory Mechanisms
Jan 26, 2022
Although the gene YBX2 is not the direct cause of cancer, it seems to be inextricably linked to cancer, and the latest research shows that high YBX2 expression is unfavorable in prognosis of endometrial cancer. Read More >
Weekly Gene
[Weekly Gene]—The 'culprit' of Osteoarthritis - ADAMTS5
Jan 14, 2022
On the 21st anniversary of the discovery of ADAMTS-5, this article looks at its deleterious effects in development of Osteoarthritis (OA). Read More >
Weekly Gene
[Weekly Gene]—Will the MARCHF2 Gene be the Next Research Hotspot?
Dec 30, 2021
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC Read More >
Weekly Gene
[Weekly Gene]—Targeting INPP5E in Rare Disease
Dec 21, 2021
INPP5E (Inositol Polyphosphate-5-Phosphatase E) is a Protein Coding gene. Diseases associated with INPP5E include Joubert Syndrome 1 and Mental Retardation, Truncal Obesity, Retinal Dystrophy, and Micropenis (MORM) Syndrome. Read More >
Weekly Gene
[Weekly Gene]—Targeting STAT3 in Rare Disease
Dec 09, 2021
The STAT3 (Signal Transducer And Activator Of Transcription 3) gene is part of the STAT gene family. Read More >