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Weekly Gene
【Gene of the Week】Metabolism & Cardiovascular Diseases - SIRT3
Feb 26, 2021
The SIRT3 gene plays an important role in the pathogenesis of metabolic, cardiovascular, and neurodegenerative diseases. In this article, we review the functionality of SIRT3 and explore its role in metabolism & cardiovascular disease studies - bringing together insights to SIRT3 gene research developments to provide inspiration for your scientific innovation. Read More >
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Video
The PiggyBAC Transposon - Generating Transgenic Mice with Consistent Expression
Feb 23, 2021
In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option. Read More >
Weekly Gene
[Gene of the Week] The Next Generation Target for Immunotherapy - CD134 (TNFRSF4)
Feb 18, 2021
Immune checkpoint proteins (ICP) are a group of signaling molecules possessed by immune cells that can regulate and control the persistence of immune response. The immune checkpoint signaling pathway consists of inhibitory and stimulatory pathways that maintain self-tolerance and assist with the immune response. Read More >
Research Trend
Newsletter
COVID-19
Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology
Feb 09, 2021
The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More >
One-Minute Survey: Cyagen Knockout Catalog Models Improve our offerings and receive $2,000 credit!
Feb 04, 2021
Given your interest in and/or purchase from the Cyagen Knockout Catalog Models repository, we would appreciate your participation in a one-minute survey. Your feedback will be used to improve our catalog offerings. Read More >
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Video
Pronuclear Injection-based Transgenic Mouse Model Generation
Feb 02, 2021
Transgenic mice are important tools for scientists researching heritable traits and diseases in human populations. In traditional transgenics, the human gene (packaged in a transgenic construct) can be added to the mouse genome with a simple pronuclear injection into the male pronucleus. Read More >
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Research Trend
2020 In Review: Top 10 Custom Mouse Model Publications
Jan 22, 2021
As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study. Read More >
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Video
How Knockout Mice are Developed with Traditional Gene Targeting
Jan 15, 2021
From the creation of the first knockout (KO) mouse, scientists have come extremely far. CRISPR technologies have quickly become a leading method used by genetic knockout scientists today, in part due to the method’s short turnaround. Read More >
Latest Discovery
Research Trend
Novel Mouse Model for Researching RAB7A and NF-kB Activation
Jan 12, 2021
A recent study has suggested that that NF-kB activation is boosted by colocalization of engaged immune receptors (i.e., CD40) with RAB7 small GTPase on mature endosomes in mouse B cells. This research was enabled by using a conditional (floxed) gene knockin mouse model - Cd19+/creRosa26+/fl-STOP-fl-Rab7 (Rab7 B-Tg) – which is designed to express untagged RAB7 in CD19+ B cells. Read More >
Newsletter
Weekly Gene
[Gene of the Week] Alzheimer's Disease and Genes - APOE (Apolipoprotein E)
Dec 22, 2020
In our fourth Gene of the Week article, we continue covering genes related to the development of Alzheimer's disease (AD). Several mutations in APOE (Apolipoprotein E) have been identified to not only increase the risk of developing AD, but other neurological and cardiovascular diseases. Read More >