Most Popular
Newsletter
Cyagen’s Checklist for Your Return to the Lab
Jul 31, 2020
As scientists around the world continue to grapple with the implications of COVID-19 on their research, Cyagen remains available to assist with all your needs for in vivo model services and products. Our expert support team understands that researchers worldwide are up against many different barriers in starting their projects. Read More >
Newsletter
New Cyagen Knockout Catalog Model Publication Alert – July 2020
Jul 28, 2020
From January through June of 2020, Cyagen received over 70 citations for our animal models, contributing to many advances across research fields. We have put together the below list of articles from high impact factor (IF) journals to provide insights into a variety of mouse model types, gene targets, research applications, and some of the most recent developments shown in scientific literature. Read More >
COVID-19
Newsletter
COVID-19 Resource List for Researchers – ACE2 Animal Models and More
Jul 27, 2020
The pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge worldwide. To provide a wholistic guide for developing clinical treatments, vaccines, and antiviral drugs, it is of great significance to study the interaction mechanisms between severe acute respiratory syndrome (SARS) coronaviruses and host molecules, while also exploring the pathogenic process of coronaviruses. Read More >
Research Trend
Newsletter
Applications of Humanized Mouse Models in Drug Development Research
Jul 16, 2020
Humanized mice can be developed through a variety of genetic modification techniques, wherein human genes may directly replace endogenous mouse genes or be inserted into a safe locus, such as Rosa26. Read More >
Research Trend
Latest Discovery
Applications of Rat Models in Alzheimer's Disease Discovery Research
Jul 14, 2020
The predominant animal models currently used in the research of Alzheimer's disease (AD) are genetically modified mice. Although promising results have been achieved in this field, almost all corresponding clinical trials have failed, especially with regards to drug development centered on the amyloid hypothesis. Read More >
Research Trend
Using S100a9 Knockout Mice to Identify Therapeutic Targets for MI/R Injury
Jul 10, 2020
The human S100A9 gene encodes the S100 calcium-binding protein A9 (S100A9). In mammals, S100A8 and S100A9 proteins form a heterodimer known as calprotectin. Calprotectin is involved in the inflammatory process - it is known to be present as a soluble protein in the cytosol of neutrophil granulocytes, and is found in lower concentrations among in monocytes, macrophages, and squamous epithelial cells. Read More >
COVID-19
Research Trend
Mouse Models for SARS - Construction Strategies and Applications
Jul 09, 2020
Recent news continues to show that the COVID-19 pandemic situation globally is far from being over. Across the entire world, the pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge. Read More >
COVID-19
Research Trend
From Bats to Humans: How SARS-CoV-2 Jumped Across Species
Jun 29, 2020
Although the origin of the new coronavirus remains inconclusive, according to the analysis of existing genomic data, the scientific community has drawn preliminary conclusions that bats may be the reservoir species for the novel coronavirus (SARS-CoV-2). If this view is proved to be credible, how does the virus jump from a bat to a human? Read More >
Newsletter
Advantages of TurboKnockout® Gene Targeting Mice
Jun 28, 2020
The TurboKnockout® gene targeting service by Cyagen is based on traditional embryonic stem cell (ESC)-mediated targeting techniques, which can be used for complex gene knockout projects to provide C57BL/6 or (new) BALB/c mouse models with accurate genetic modification and no off-target effects. Read More >
Newsletter
New Cyagen Mice Publication Alert – June 2020
Jun 19, 2020
The following publications demonstrate the use of custom genetically modified mouse and rat models across a broad range of human disease studies, including immunological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and liver disease. Read More >