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- > How to Make A Lentiviral Overexpression Vector?
- > What are the Strategies for Gene Therapy?
- > BALB/c vs C57BL/6 Mice: Key Differences for Research Models
- > ROSA26: The ‘Safe Harbor’ Locus in the Mouse Genome
Most Popular
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Research Trend
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| KO-First: A Tool for Studying Gene Function Across the Mammalian Genome |
| Sep 27, 2019 |
| Since the early 2000s, large-scale knockout consortia have been established with the goal of generating a complete resource of reporter-tagged null mutations in C57BL/6 mouse ES cells. Herein, we provide a brief introduction to the ‘knockout-first’ (KO-first) Read More > |
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Breaking News
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| Targeted Gene Editing-Pro: How the Patent Dispute has Transformed Science Innovation |
| Sep 10, 2019 |
| As Targeted Gene Editing-based innovations begin to move into clinical testing and the dispute over core patents continues worldwide, Targeted Gene Editing-Pro gene editing has been under increased scrutiny in both commercial and academic sectors. Read More > |
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Research Trend
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| RPS23RG1-mediated Stabilization of Synaptic Function Rescues AD-Associated Cognitive Deficits |
| Aug 13, 2019 |
| Synaptic impairment is known to be a prerequisite to the cognitive deficiencies exhibited in Alzheimer's Disease (AD), so investigating the mechanisms which Read More > |
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Latest Discovery
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| Advancing the Study of Cardiac Chamber Specification During Development & Pathological Remodeling |
| Aug 06, 2019 |
| Nppa (natriuretic peptide A) is a cardiac hormone that dynamically changes its spatiotemporal expression during heart development. Read More > |
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Research Trend
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| The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research |
| Jul 24, 2019 |
| Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Read More > |
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Research Trend
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| Improving Cancer Models with Humanized Mice |
| Jul 09, 2019 |
| Mouse models have been instrumental in elucidating the pathobiology of cancer formation and inhibition, including that of Colorectal Cancers (CRC) and Prostate Cancers. Read More > |
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Newsletter
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| Custom Animal Models for Improving Human Disease Research |
| Jun 24, 2019 |
| If your lab is working on research projects that utilize mouse/rat models, off-the-shelf models often come with limitations that may be addressed through genomic modifications to improve homology. Read More > |
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Research Trend
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| Application of Toll-Like Receptors (TLRs) Animal Models in Cancer and Autoimmune Disorders |
| Jun 17, 2019 |
| Toll-like receptors (TLRs) are a class of transmembrane proteins that play essential roles in mammalian innate immune responses against infection. In general, TLRs can recognize structurally conserved molecules, collectively referred to Read More > |
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Research Trend
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| Custom Animal Models of Neurodegeneration for Investigation of Potential Therapeutics |
| Jun 12, 2019 |
| Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis, such as tau accumulation, amyloid-β deposition, and altered network oscillations. Synaptic and neuronal loss are also typical of many of neurodegenerative diseases Read More > |
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Research Trend
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| How microRNA may be used to promote heart regeneration |
| Jun 05, 2019 |
| Recent research has aimed to enhance the regeneration capacity of adult cardiomyocytes (CMs), in part by addressing their withdrawal from the cell cycle following myocardial infarction (MI). As a suggested regulator of endogenous CM proliferation Read More > |
