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COVID-19
ACE2 Catalog Models – Humanized, Conditional Knockin, and Knockout Mice
Aug 27, 2020
As the leading provider of custom animal model generation services, Cyagen’s R&D team began developing mouse models for studying the novel coronavirus in the early stages of the COVID-19 outbreak. Read More >
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Latest Discovery
RALY Gene Feature: New Implications in Metabolism and Cholesterogenesis
Aug 18, 2020
The heterogenous nuclear ribonucleoprotein (hnRNP) family are multifunctional complexes of RNA and protein present in the cell nucleus that serve critical roles in gene regulation. Multiple lines of evidence have linked hnRNP abnormalities as key pathobiological drivers of cancer and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Read More >
Research Trend
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Applications of Humanized Mouse Models in Drug Development Research
Jul 16, 2020
Humanized mice can be developed through a variety of genetic modification techniques, wherein human genes may directly replace endogenous mouse genes or be inserted into a safe locus, such as Rosa26. Read More >
Research Trend
Latest Discovery
Applications of Rat Models in Alzheimer's Disease Discovery Research
Jul 14, 2020
The predominant animal models currently used in the research of Alzheimer's disease (AD) are genetically modified mice. Although promising results have been achieved in this field, almost all corresponding clinical trials have failed, especially with regards to drug development centered on the amyloid hypothesis. Read More >
Research Trend
Using S100a9 Knockout Mice to Identify Therapeutic Targets for MI/R Injury
Jul 10, 2020
The human S100A9 gene encodes the S100 calcium-binding protein A9 (S100A9). In mammals, S100A8 and S100A9 proteins form a heterodimer known as calprotectin. Calprotectin is involved in the inflammatory process - it is known to be present as a soluble protein in the cytosol of neutrophil granulocytes, and is found in lower concentrations among in monocytes, macrophages, and squamous epithelial cells. Read More >
COVID-19
Research Trend
Mouse Models for SARS - Construction Strategies and Applications
Jul 09, 2020
Recent news continues to show that the COVID-19 pandemic situation globally is far from being over. Across the entire world, the pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge. Read More >
COVID-19
Research Trend
From Bats to Humans: How SARS-CoV-2 Jumped Across Species
Jun 29, 2020
Although the origin of the new coronavirus remains inconclusive, according to the analysis of existing genomic data, the scientific community has drawn preliminary conclusions that bats may be the reservoir species for the novel coronavirus (SARS-CoV-2). If this view is proved to be credible, how does the virus jump from a bat to a human? Read More >
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Latest Discovery
COVID-19
Factors Contributing to the Age and Sex-Based Differences of the Novel Coronavirus - SARS-CoV-2/COVID-19
Jun 16, 2020
With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups. Read More >
Research Trend
Latest Discovery
COVID-19
Differences in COVID-19 Severity Across Patient Populations - Age and Gender
Jun 12, 2020
With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups. Read More >
Research Trend
MyD88 Signaling Pathway & IL-33 Induced Immune Response
Jun 08, 2020
The MYD88 gene encodes a cytosolic adapter protein, MyD88, which is involved in signaling for both the innate and adaptive immune response. The MyD88 adapter protein is essential for transducing signals in the interleukin-1 (IL-1) and toll-like receptor (TLR) pathways, which regulate activation of proinflammatory genes, and stimulating signaling molecules that activate interacting proteins called nuclear factor-kappa-B (NF-κB). Read More >