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Animal Models of Non-Alcoholic Fatty Liver Disease (NAFLD) and Steatohepatitis (NASH)
Jun 04, 2020
Non-alcoholic fatty liver disease (NAFLD), a hepatopathy syndrome affecting both adults and children, is characterized by a range of liver conditions affecting people who consume little to no alcohol, including simple fatty liver, steatohepatitis, fatty liver fibrosis, and cirrhosis. NAFLD can progress from simple fatty liver through nonalcoholic steatohepatitis (NASH) to liver fibrosis, and even lead to end-stage liver diseases, such as, liver cirrhosis, hepatocellular carcinoma (HCC), or liver failure. Read More >
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The Latest Animal Models of Chronic Pancreatitis
May 28, 2020
While chronic pancreatitis (CP) is a relatively common disease, it remains difficult to treat. This is defined as a continuous or recurrent inflammatory pancreatic disease characterized by progressive and irreversible changes in pancreatic morphology. So far, scholars around the globe have done a lot of research on the diagnosis, treatment, and pathogenesis of the disease. Read More >
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COVID-19
Understanding SARS-CoV-2: From the Origin to Current Research
May 13, 2020
The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an ongoing global health emergency. Herein, we track the virus from its origin to current research efforts, with the aim of providing inspiration for further research and vaccine development. Read More >
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COVID-19
Applications of Mouse Models for the Study of Coronavirus Diseases in Humans
May 07, 2020
The World Health Organization (WHO) announced the reclassification of the COVID-19 outbreak as a global pandemic on March 11, 2020. With the rapid spread of the disease across the globe, countries worldwide have joined the war against the SARS-CoV-2 virus. Read More >
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Parkinson’s Disease (PD) – Researching Genetic Factors with Animal Models
Apr 29, 2020
Although most cases of Parkinson’s Disease (PD) are idiopathic, there is a small fraction of cases that have known genetic factors – presented in diagnoses of familial PD. Roughly 5% -15% of PD cases are due to a mutation occurring in one of several specific genes, commonly designated as PARK genes (due to their association with PD). Read More >
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COVID-19
Complete Collection: The Hottest Mouse Models for Coronavirus Research
Apr 10, 2020
The World Health Organization (WHO) announced the reclassification of the COVID-19 outbreak as a global pandemic on March 11, 2020. With the rapid spread of the disease across the globe, countries worldwide have joined the war against the SARS-CoV-2 virus, for which, early prevention, control, and treatment may provide valuable tools against the pandemic. Read More >
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Applications of Sirtuins (SIRT) Knockout Mouse Models in Disease Research
Apr 07, 2020
Sirtuins - colloquially known as the longevity genes – are a highly conserved family of NAD1+-dependent enzymes which are involved in the regulation of gene silencing, metabolism, cell division, apoptosis, and genetic material repair. Additionally, it has been reported that sirtuins play important roles in the development of multi-systemic diseases. Read More >
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COVID-19
Beyond Mediating Host Cell Entry of SARS-CoV-2: What Roles Does ACE2 Play?
Apr 01, 2020
In our fight against the virus and COVID-19, researchers have studied the SARS-CoV-2 virus itself and its host receptor, ACE2, from the aspects of epidemiology, pathology, virus traceability, prevention, and control measures. The human ACE2 receptor is known to interact with SARS-CoV-2 and permit its initial cell entry, making it particularly important to explore its function. Read More >
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How to Choose the Right Mouse Models and Genetic Modification Method for Your Research
Mar 30, 2020
Our experts put together the following advice on how to choose the most suitable mouse strains & genetic modification techniques for your research. In practical applications, it is necessary to select mouse strain backgrounds that align with your desired research applications to achieve good experimental results. Read More >
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Research Trend
COVID-19
Cytokine Storm: The New Perspective for COVID-19 Research
Mar 19, 2020
Since COVID-19 poses a significant threat to public health and also represents a challenge for antiviral drug development and administration globally, current efforts focus on prevention and control while accelerating the research on the SARS-CoV-2 coronavirus, which has caused the outbreak of COVID-19. Read More >