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COVID-19
Researching the New Coronavirus, SARS-CoV-2: Applications for Animal Models
Mar 10, 2020
The novel coronavirus, now officially designated as SARS-CoV-2, was first identified in Wuhan, Hubei Province, China in December of 2019. This virus has led to an outbreak of COVID-19 (Coronavirus Disease in 2019), which is associated with acute respiratory illness and infection, as is common for diseases caused by the coronavirus family. Read More >
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Coronaviruses and SARS-CoV-2 – Host Receptor-Mediated Infection Mechanisms & Potential Antiviral Treatments
Mar 10, 2020
At the end of 2019, a large-scale illness broke out from Wuhan, Hubei Province - a central province of China. The virus that cased this illness could enter the respiratory tract through droplets - moreover, the increasingly busy traffic conditions and travel around the holiday season made the virus spread extremely rapidly. Read More >
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COVID-19
Beyond ACE2: Additional Targets of Significance for Coronavirus Research
Mar 10, 2020
At present, the prevention and treatment of coronavirus is the most urgent issue for scientific and medical research. In addition to the ACE2 host receptor target that is being highly focused on, what other targets deserve the attention of current coronavirus researchers? Read More >
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White Paper: Infectivity and Immune Mechanisms of Coronaviruses & SARS-CoV-2
Feb 27, 2020
An outbreak of COVID-19 (Coronavirus Disease in 2019) caused by the novel coronavirus, officially named SARS-CoV-2, swept across the world from Wuhan at the end of 2019 - having since brought a huge impact on the lives of people both in China and abroad. Read More >
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A Guide to Stem Cell Research: Disease Models and Clinical Applications in 2020
Jan 21, 2020
This guide offers a quick introduction to stem cells, current stem cell research efforts, widely-used stem cell treatments, and clinical trials currently underway in 2020. Read More >
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Differentiating the Biological Functions of Nestin with Transgenic Mice
Nov 12, 2019
Since the identification of the intermediate filament (IF), nestin, it has been used as a marker for Neural Stem Cells (NSCs) and commonly considered as a key component of the cytoskeleton. Read More >
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KO-First: A Tool for Studying Gene Function Across the Mammalian Genome
Sep 27, 2019
Since the early 2000s, large-scale knockout consortia have been established with the goal of generating a complete resource of reporter-tagged null mutations in C57BL/6 mouse ES cells. Herein, we provide a brief introduction to the ‘knockout-first’ (KO-first) Read More >
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RPS23RG1-mediated Stabilization of Synaptic Function Rescues AD-Associated Cognitive Deficits
Aug 13, 2019
Synaptic impairment is known to be a prerequisite to the cognitive deficiencies exhibited in Alzheimer's Disease (AD), so investigating the mechanisms which Read More >
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The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research
Jul 24, 2019
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Read More >
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Improving Cancer Models with Humanized Mice
Jul 09, 2019
Mouse models have been instrumental in elucidating the pathobiology of cancer formation and inhibition, including that of Colorectal Cancers (CRC) and Prostate Cancers. Read More >