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Application of Toll-Like Receptors (TLRs) Animal Models in Cancer and Autoimmune Disorders
Jun 17, 2019
Toll-like receptors (TLRs) are a class of transmembrane proteins that play essential roles in mammalian innate immune responses against infection. In general, TLRs can recognize structurally conserved molecules, collectively referred to Read More >
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Custom Animal Models of Neurodegeneration for Investigation of Potential Therapeutics
Jun 12, 2019
Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis, such as tau accumulation, amyloid-β deposition, and altered network oscillations. Synaptic and neuronal loss are also typical of many of neurodegenerative diseases Read More >
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How microRNA may be used to promote heart regeneration
Jun 05, 2019
Recent research has aimed to enhance the regeneration capacity of adult cardiomyocytes (CMs), in part by addressing their withdrawal from the cell cycle following myocardial infarction (MI). As a suggested regulator of endogenous CM proliferation Read More >
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Treatment and Male-Bias in Autistic Mice
Jan 22, 2018
Although humans and mice are separated by 100 million years of evolution, mouse and rat models have continually proven themselves as extremely powerful research tools. Many mouse and rat genetic models can even recapitulate complex and... Read More >
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Controlling when and where: Conditional and inducible gene expression
Jul 26, 2017
In the early days of engineered animal models, simple knockout and transgenic mice were used to examine gene function. Researchers began to dissect the roles of individual genes by studying phenotypes of mice lacking or... Read More >
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Optogenetics: Light-control of genes, pathways, and cells
Jul 12, 2017
Optogenenetics refers to a family of techniques which allow modulation of biological processes using light. Over the past 12 years, optogenetics has... Read More >
Research Trend
Making mice live longer, then humans
Jun 28, 2017
Invariably, everyone gets old. However, as a true testament to human stubbornness, research toward a “cure” for aging has never stopped. Over the past... Read More >