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Research Trend
2020 In Review: Top 10 Custom Mouse Model Publications
Jan 22, 2021
As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study. Read More >
Latest Discovery
Research Trend
Novel Mouse Model for Researching RAB7A and NF-kB Activation
Jan 12, 2021
A recent study has suggested that that NF-kB activation is boosted by colocalization of engaged immune receptors (i.e., CD40) with RAB7 small GTPase on mature endosomes in mouse B cells. This research was enabled by using a conditional (floxed) gene knockin mouse model - Cd19+/creRosa26+/fl-STOP-fl-Rab7 (Rab7 B-Tg) – which is designed to express untagged RAB7 in CD19+ B cells. Read More >
Research Trend
Newsletter
White Paper
Applications of the Mouse Model in Translational Medical Research
Nov 16, 2020
The mouse model has become an irreplaceable model organism for biomedical research, which includes studying gene function and genetic factors of pathogenesis, establishing humanized disease models, and evaluating the safety and effectiveness of drugs under development. Read More >
Weekly Gene
Research Trend
[Gene of the Week] Alzheimer's Disease and Genes - PSEN1 (Presenilin 1)
Nov 12, 2020
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. In this review, we discuss the current research and understanding of the PSEN1 gene and its mutation which causes familial Alzheimer's disease (FAD). Read More >
Newsletter
Research Trend
Genes of Fear – Halloween Special
Oct 29, 2020
Happy Halloween from Cyagen! To celebrate and educate, our team has put together brief synopses of several genes related to fear: STMN1, P4H-TM, ANXA1, FPR1, DAGLA, and TAAR1. Read on to learn about each gene’s functions, research progress, and opportunities for discovery. Read More >
Research Trend
Weekly Gene
[Gene of the Week] Alzheimer's Disease and Genes - APP (Amyloid Precursor Protein)
Oct 21, 2020
It is well known that genes play a major role in many human diseases - for this reason they are an important research topic in the field of life science and medicine. How can the public quickly grasp the recent research on disease-related genes, when the only resources out about them are long complex academic journals? Read More >
Research Trend
Introduction to the Cre-Lox Recombination System
Oct 20, 2020
With the advantages of simple operation and high recombination rate, the Cre-Lox system has now become a powerful tool for genetic manipulation across in vivo and in vitro. The Cre-Lox system enables gene expression with exceptional spatial (expresses a gene in specific cells, tissues, or entire organisms) and temporal (at specific time points through the application of the Cre-Lox system) control. Read More >
White Paper
Research Trend
Conditional Rat Models for Human Disease Research
Sep 21, 2020
Rats are an ideal animal model for human disease research – compared to mice, rats are physiologically, morphologically, and genetically closer to humans – as covered in our recent Technical Bulletin. Since the first targeted knockout (KO) rat was developed in 2010, significant progress has been made in their use as experimental model animals in basic research, drug screenings, and preclinical drug evaluations. Read More >
Newsletter
Research Trend
Rats - The Animal Model that is Revitalizing Medical Research
Sep 09, 2020
Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. Mice are considered the most important model animal for analyzing human gene functions due to its small size, low operational costs, relatively stable embryonic cells, and pliability for various genetic manipulations and gene editing. Read More >
Research Trend
COVID-19
Research Progress on SARS-CoV-2 Neutralizing Antibody and Vaccines
Aug 31, 2020
Though the current situation regarding COVID-19 is still severe, since July, many successes have been achieved on SARS-CoV-2 neutralizing antibody and Phase II clinical trials of SARS-CoV-2 vaccines. With the effort of scientists worldwide, results indicate that research will continue to make progress in the fight against COVID-19. Read More >