Atherosclerosis Mouse Model (Gene-editing)

Atherosclerosis Mouse Model (Gene-editing)

 

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Apoe and Ldlr gene knockout (KO) mice can spontaneously form atherosclerotic plaques and are widely used in atherosclerosis (AS) studies.

 

1. ApoE Knockout Mice

The Apolipoprotein E-deficient (apoEKO) mice, as a model of spontaneously developed atherosclerosis, are most similar to the human atherosclerosis process. ApoE is a component of very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL), and is involved in the cholesterol transport. Contrary to human lipoprotein profile, mice have higher level of HDL but lower low-density lipoprotein (LDL), and mice carry most of their cholesterol in HDL. Cholesterol of apoEKO mice is largely distributed in VLDL, and high amounts of cholesterol it carries cannot be bound by lipoprotein receptors on the cell surface and degraded, resulting in accumulation and atherosclerosis. Studies have shown that ApoE-/- mice can spontaneously develop hypercholesterolemia (300-500 mg/dL), and significant atherosclerotic lesions under normal diet conditions. The high-cholesterol/high-fat (HCHF) atherogenic diet will increase the plasma cholesterol level by more than 1000 mg/dL and accelerate the atherosclerosis process. The level of triacylglycerol in the plasma of ApoE-/- mice is 68% higher than that of normal mice, regardless age and gender, while its high-density lipoprotein (HDL) is only 45% of normal mice. The lesions of ApoE-/- mice mainly occur in the aortic root, aortic arch, innominate artery, aortic branch and renal artery bifurcation. Under normal diet conditions, early foam cell lesions can occur within 10 weeks, and developed into atherosclerotic lesions after 15 weeks, and advanced fibrosis after 20 weeks. A high-cholesterol/high-fat (HCHF) diet can accelerate the atherosclerosis process., including the formation of cholesterol crystals, necrotic cores, and calcifications.

Health Standard: SPF

 

2. LDLR Gene Knockout Mice

Low density lipoprotein receptor (LDLR) gene knockout (KO) mice are currently one of the most popular genetically engineered animal models in atherosclerosis (AS) research. LDLR knockout mice can hardly absorb low density lipoprotein (LDL), which leads to chronic high levels of LDL in the plasma, promoting the process of lipid infiltration and inducing atherosclerosis. Researchers discovered infiltration of mast cells is the vital step in the process of atherosclerosis inflammatory reaction by studying Ldlr-/- mice - as either the removal of mast cells or the degranulation of a mast cells can significantly reduce the formation of atherosclerosis. This research is of great significance to the prevention and treatment of atherosclerosis.

Detection Items: Body weight, food intake, serum biochemical test or ELISA test, morphology of aortic arch pathology (Arterial Tissues H&E staining, oil red, measure the area proportion of plaque in artery intima and Cross Section)

 

3. Other Genetically Modified Mouse Models Related to Atherosclerosis Research

Gene Backgrounds Storing Status
4930544G11Rik C57BL/6J Cryopreserved Sperms
Actb C57BL/6J Cryopreserved Sperms
Acvr1 C57BL/6J Cryopreserved Sperms
Acvr2a C57BL/6J Cryopreserved Sperms
Acvr2b C57BL/6J Cryopreserved Sperms
Akt1 C57BL/6N Cryopreserved Sperms
Akt2 C57BL/6J Cryopreserved Sperms
Akt3 C57BL/6J Cryopreserved Sperms
Arhgef2 C57BL/6J Cryopreserved Sperms
Ass1 C57BL/6J Cryopreserved Sperms
BC051665 C57BL/6J Cryopreserved Sperms
Bcl2 C57BL/6J Cryopreserved Sperms
Bmp4 C57BL/6J Cryopreserved Sperms
Bmpr1a C57BL/6J Cryopreserved Sperms
Bmpr1b C57BL/6J Cryopreserved Sperms
Bmpr2 C57BL/6J Cryopreserved Sperms
Calm1 C57BL/6J Cryopreserved Sperms
Calm2 C57BL/6J Cryopreserved Sperms
Calm3 C57BL/6J Cryopreserved Sperms
Calml3 C57BL/6J Cryopreserved Sperms
Calml4 C57BL/6J Cryopreserved Sperms
Cav1 C57BL/6N Cryopreserved Sperms
Cav2 C57BL/6N Cryopreserved Sperms
Cav3 C57BL/6N Cryopreserved Sperms
Ccl12 C57BL/6J Cryopreserved Sperms
Ccl2 C57BL/6N Cryopreserved Sperms
Cdh5 C57BL/6J Cryopreserved Sperms
Chuk C57BL/6J Cryopreserved Sperms
Ctnnb1 C57BL/6N Cryopreserved Sperms
Cts6 C57BL/6J Cryopreserved Sperms
Ctsl C57BL/6J Cryopreserved Sperms
Ctsll3 C57BL/6J Cryopreserved Sperms
Cyba C57BL/6J Cryopreserved Sperms
Dusp1 C57BL/6N Cryopreserved Sperms
Edn1 C57BL/6J Cryopreserved Sperms
Fos C57BL/6J Cryopreserved Sperms
Gpc1 C57BL/6J Cryopreserved Sperms
Gsta3 C57BL/6J Cryopreserved Sperms
Gsta4 C57BL/6J Cryopreserved Sperms
Gstm1 C57BL/6J Cryopreserved Sperms
Gstm2 C57BL/6J Cryopreserved Sperms
Gstm3 C57BL/6J Cryopreserved Sperms
Gstm4 C57BL/6J Cryopreserved Sperms
Gstm5 C57BL/6J Cryopreserved Sperms
Gstm6 C57BL/6J Cryopreserved Sperms
Gstm7 C57BL/6J Cryopreserved Sperms
Gsto1 C57BL/6J Cryopreserved Sperms
Gsto2 C57BL/6J Cryopreserved Sperms
Gstp1 C57BL/6J Cryopreserved Sperms
Gstp2 C57BL/6J Cryopreserved Sperms
Gstp3 C57BL/6J Cryopreserved Sperms
Gstt1 C57BL/6J Cryopreserved Sperms
Gstt2 C57BL/6J Cryopreserved Sperms
Gstt3 C57BL/6J Cryopreserved Sperms
Gstt4 C57BL/6J Cryopreserved Sperms
Hsp90b1 C57BL/6J Cryopreserved Sperms
Icam1 C57BL/6J Cryopreserved Sperms
Ifng C57BL/6N Cryopreserved Sperms
Ikbkb C57BL/6J Cryopreserved Sperms
Ikbkg C57BL/6J Cryopreserved Sperms
Il1a C57BL/6N Cryopreserved Sperms
Il1b C57BL/6N Cryopreserved Sperms
Il1r1 C57BL/6J Cryopreserved Sperms
Il1r2 C57BL/6N Cryopreserved Sperms
Itga2b C57BL/6J Cryopreserved Sperms
Itgav C57BL/6J Cryopreserved Sperms
Itgb3 C57BL/6J Cryopreserved Sperms
Jun C57BL/6J Cryopreserved Sperms
Kdr C57BL/6J Cryopreserved Sperms
Keap1 C57BL/6J Cryopreserved Sperms
Klf2 C57BL/6J Cryopreserved Sperms
Map2k4 C57BL/6J Cryopreserved Sperms
Map2k5 C57BL/6J Cryopreserved Sperms
Map2k6 C57BL/6J Cryopreserved Sperms
Map2k7 C57BL/6J Cryopreserved Sperms
Map3k5 C57BL/6N Cryopreserved Sperms
Map3k7 C57BL/6J Cryopreserved Sperms
Mapk10 C57BL/6J Cryopreserved Sperms
Mapk11 C57BL/6J Cryopreserved Sperms
Mapk12 C57BL/6J Cryopreserved Sperms
Mapk13 C57BL/6J Cryopreserved Sperms
Mapk14 C57BL/6J Cryopreserved Sperms
Mapk7 C57BL/6J Cryopreserved Sperms
Mapk8 C57BL/6J Cryopreserved Sperms
Mapk9 C57BL/6J Cryopreserved Sperms
Mef2a C57BL/6J Cryopreserved Sperms
Mef2c C57BL/6J Cryopreserved Sperms
Mgst1 C57BL/6J Cryopreserved Sperms
Mgst2 C57BL/6J Cryopreserved Sperms
Mgst3 C57BL/6J Cryopreserved Sperms
Mmp2 C57BL/6N Cryopreserved Sperms
Mmp9 C57BL/6N Cryopreserved Sperms
Ncf1 C57BL/6J Cryopreserved Sperms
Ncf2 C57BL/6J Cryopreserved Sperms
Nfe2l2 C57BL/6N Cryopreserved Sperms
Nfkb1 C57BL/6J Cryopreserved Sperms
Nos3 C57BL/6N Cryopreserved Sperms
Nox1 C57BL/6J Cryopreserved Sperms
Nppc C57BL/6J Cryopreserved Sperms
Nqo1 C57BL/6J Cryopreserved Sperms
Pdgfa C57BL/6J Cryopreserved Sperms
Pdgfb C57BL/6J Cryopreserved Sperms
Pecam1 C57BL/6N Cryopreserved Sperms
Pias4 C57BL/6J Cryopreserved Sperms
Pik3ca C57BL/6J Cryopreserved Sperms
Pik3cb C57BL/6J Cryopreserved Sperms
Pik3cd C57BL/6J Cryopreserved Sperms
Pik3r1 C57BL/6J Cryopreserved Sperms
Pik3r2 C57BL/6J Cryopreserved Sperms
Pik3r3 C57BL/6J Cryopreserved Sperms
Plat C57BL/6J Cryopreserved Sperms
Prkaa1 C57BL/6N Cryopreserved Sperms
Prkaa2 C57BL/6N Cryopreserved Sperms
Prkcz C57BL/6J Cryopreserved Sperms
Ptk2 C57BL/6J Cryopreserved Sperms
Rac1 C57BL/6J Cryopreserved Sperms
Rac2 C57BL/6J Cryopreserved Sperms
Rac3 C57BL/6J Cryopreserved Sperms
Rela C57BL/6J Cryopreserved Sperms
Rhoa C57BL/6J Cryopreserved Sperms
Sdc1 C57BL/6N Cryopreserved Sperms
Sdc2 C57BL/6J Cryopreserved Sperms
Sdc4 C57BL/6N Cryopreserved Sperms
Sele C57BL/6J Cryopreserved Sperms
Sqstm1 C57BL/6N Cryopreserved Sperms
Src C57BL/6J Cryopreserved Sperms
Sumo1 C57BL/6N Cryopreserved Sperms
Sumo2 C57BL/6J Cryopreserved Sperms
Thbd C57BL/6J Cryopreserved Sperms
Tnf C57BL/6N Cryopreserved Sperms
Tnfrsf1a C57BL/6N Cryopreserved Sperms
Trp53 C57BL/6J Cryopreserved Sperms
Trpv4 C57BL/6N Cryopreserved Sperms
Txn1 C57BL/6J Cryopreserved Sperms
Txn2 C57BL/6J Cryopreserved Sperms
Vegfa C57BL/6J Cryopreserved Sperms

 

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