Diet-induced obesity (DIO) Model

Diet-induced obesity (DIO) Model


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The diet-induced obesity (DIO) model recapitulates metabolic factors implicated in human obesity, which has led to its use in studying the relationship between diet, genes, and other factors in the developmental processes of obesity, diabetes, and related metabolic disorders. Cyagen’s DIO mouse models are developed by feeding a high-calorie diet and may be used for preclinical efficacy studies of obesity and related complications.

Background: C57BL/6J

Weight: Greater than 18g, the average value is preferably about 20g.

Experimental groups: There are five experimental groups - model control group, positive control group, low-dose group, medium-dose group, and high-dose group.

Testing items: Weight, food intake, Cholesterol and lipid tests (ALT, AST, TG, Chol, HDL-C, LDL-C, etc.), adipose tissue collection and pathological analysis, PCR testing, etc.


Cyagen can provide you with a variety of drug evaluation models along with  phenotype analysis services – delivering reliable and expedient data reporting for your project.


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Why work with Cyagen?

  • 14+ years' experience in custom animal model generation
  • 50,000+ animal models generated and delivered worldwide
  • 4,000+ citations in SCI journals for our services
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