Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)

 

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The production and clearance of fat in liver cells is regulated by a variety of genes - of which, mutation, deletion, overexpression, or modification may affect fat metabolism, thereby forming fatty liver. Human genes associated with MASLD pathologies can be replicated across species by targeting analogous genes to develop this specific MASLD animal model.

 

1. Pten Gene Knockout Mice

Phosphatase and tensin homolog (PTEN) is a lipid phosphatase involved in the fatty acid β-oxidation (FAO) of hepatic cells and triacylglycerol synthesis, which also plays the role as a negative regulator in signaling pathways such as apoptosis, cell proliferation and differentiation, and tumor formation. One study found that liver damage discovered in liver tissue-specific Pten gene knockout mice is similar to that of human MASH. Such mice can successively develop steatohepatitis, liver fibrosis, and liver adenoma within 10 weeks of age, with up to 66% of the cohort pathology complicated with HCC.

 

2. Apoe Gene Knockout Mice

Apoe (apolipoprotein E) gene knockout (KO) mice are commonly used in atherosclerosis (AS) studies. Interestingly, Apoe KO mice which are fed a high-fat, high-cholesterol diet can develop metabolic dysfunction-associated steatohepatitis (MASH) phenotypes, such as steatosis, inflammation, and fibrosis.

Detection Items: Body weight, food intake, serum biochemical test (alanine aminotransferase, aspartate aminotransferase, serum total cholesterol, triglyceride content, etc.), pathological analysis of liver tissue (liver tissue H&E staining, oil red).

 

3. Other Genetically Modified Mouse Models Related to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Research

Gene Backgrounds Storing Status
Adipoq C57BL/6N Cryopreserved Sperms
Adipor1 C57BL/6J Cryopreserved Sperms
Adipor2 C57BL/6J Cryopreserved Sperms
Akt1 C57BL/6N Cryopreserved Sperms
Akt2 C57BL/6J Cryopreserved Sperms
Akt3 C57BL/6J Cryopreserved Sperms
Atf4 C57BL/6J Cryopreserved Sperms
Bax C57BL/6J Cryopreserved Sperms
Bcl2l11 C57BL/6J Cryopreserved Sperms
Bid C57BL/6J Cryopreserved Sperms
Casp3 C57BL/6J Cryopreserved Sperms
Casp7 C57BL/6J Cryopreserved Sperms
Casp8 C57BL/6J Cryopreserved Sperms
Cdc42 C57BL/6J Cryopreserved Sperms
Cebpa C57BL/6J Cryopreserved Sperms
Cox4i1 C57BL/6J Cryopreserved Sperms
Cox4i2 C57BL/6J Cryopreserved Sperms
Cox5a C57BL/6J Cryopreserved Sperms
Cox5b C57BL/6J Cryopreserved Sperms
Cox6a1 C57BL/6J Cryopreserved Sperms
Cox6b1 C57BL/6J Cryopreserved Sperms
Cox6b2 C57BL/6J Cryopreserved Sperms
Cox6c C57BL/6N Cryopreserved Sperms
Cox7a1 C57BL/6J Cryopreserved Sperms
Cox7a2 C57BL/6J Cryopreserved Sperms
Cox7a2l C57BL/6N Cryopreserved Sperms
Cox7b C57BL/6J Cryopreserved Sperms
Cox7b2 C57BL/6J Cryopreserved Sperms
Cox7c C57BL/6J Cryopreserved Sperms
Cox8a C57BL/6J Cryopreserved Sperms
Cox8b C57BL/6J Cryopreserved Sperms
Cox8c C57BL/6J Cryopreserved Sperms
Cyc1 C57BL/6J Cryopreserved Sperms
Cycs C57BL/6J Cryopreserved Sperms
Cyct C57BL/6J Cryopreserved Sperms
Cyp2e1 C57BL/6J Cryopreserved Sperms
Eif2ak3 C57BL/6J Cryopreserved Sperms
Eif2s1 C57BL/6J Cryopreserved Sperms
Ern1 C57BL/6J Cryopreserved Sperms
Fas C57BL/6N Cryopreserved Sperms
Fasl C57BL/6J Cryopreserved Sperms
Fos C57BL/6J Cryopreserved Sperms
Gsk3a C57BL/6J Cryopreserved Sperms
Gsk3b C57BL/6J Cryopreserved Sperms
Ikbkb C57BL/6J Cryopreserved Sperms
Il1a C57BL/6N Cryopreserved Sperms
Il1b C57BL/6N Cryopreserved Sperms
Il6 C57BL/6N Cryopreserved Sperms
Il6ra C57BL/6N Cryopreserved Sperms
Ins1 C57BL/6J Cryopreserved Sperms
Insr C57BL/6J Cryopreserved Sperms
Irs1 C57BL/6N Cryopreserved Sperms
Itch C57BL/6J Cryopreserved Sperms
Jun C57BL/6J Cryopreserved Sperms
Lep C57BL/6J Cryopreserved Sperms
Lepr C57BL/6J Cryopreserved Sperms
Map3k11 C57BL/6J Cryopreserved Sperms
Map3k5 C57BL/6N Cryopreserved Sperms
Mapk10 C57BL/6J Cryopreserved Sperms
Mapk8 C57BL/6J Cryopreserved Sperms
Mapk9 C57BL/6J Cryopreserved Sperms
Mlx C57BL/6J Cryopreserved Sperms
Mlxip C57BL/6J Cryopreserved Sperms
Mlxipl C57BL/6N Cryopreserved Sperms
Ndufa10 C57BL/6J Cryopreserved Sperms
Ndufa11 C57BL/6J Cryopreserved Sperms
Ndufa12 C57BL/6J Cryopreserved Sperms
Ndufa13 C57BL/6J Cryopreserved Sperms
Ndufa4 C57BL/6J Cryopreserved Sperms
Ndufa4l2 C57BL/6J Cryopreserved Sperms
Ndufa6 C57BL/6J Cryopreserved Sperms
Ndufa7 C57BL/6J Cryopreserved Sperms
Ndufa8 C57BL/6J Cryopreserved Sperms
Ndufa9 C57BL/6J Cryopreserved Sperms
Ndufab1 C57BL/6J Cryopreserved Sperms
Ndufb10 C57BL/6J Cryopreserved Sperms
Ndufb11 C57BL/6J Cryopreserved Sperms
Ndufb2 C57BL/6J Cryopreserved Sperms
Ndufb3 C57BL/6J Cryopreserved Sperms
Ndufb4 C57BL/6J Cryopreserved Sperms
Ndufb5 C57BL/6J Cryopreserved Sperms
Ndufb6 C57BL/6J Cryopreserved Sperms
Ndufb8 C57BL/6J Cryopreserved Sperms
Ndufc1 C57BL/6J Cryopreserved Sperms
Ndufc2 C57BL/6J Cryopreserved Sperms
Ndufs1 C57BL/6J Cryopreserved Sperms
Ndufs2 C57BL/6J Cryopreserved Sperms
Ndufs3 C57BL/6J Cryopreserved Sperms
Ndufs4 C57BL/6J Cryopreserved Sperms
Ndufs5 C57BL/6J Cryopreserved Sperms
Ndufs6 C57BL/6J Cryopreserved Sperms
Ndufs7 C57BL/6N Cryopreserved Sperms
Ndufs8 C57BL/6J Cryopreserved Sperms
Ndufv1 C57BL/6J Cryopreserved Sperms
Ndufv2 C57BL/6J Cryopreserved Sperms
Ndufv3 C57BL/6J Cryopreserved Sperms
Nfkb1 C57BL/6J Cryopreserved Sperms
Nr1h3 C57BL/6N Cryopreserved Sperms
Pik3ca C57BL/6J Cryopreserved Sperms
Pik3cb C57BL/6J Cryopreserved Sperms
Pik3cd C57BL/6J Cryopreserved Sperms
Pik3r1 C57BL/6J Cryopreserved Sperms
Pik3r2 C57BL/6J Cryopreserved Sperms
Pik3r3 C57BL/6J Cryopreserved Sperms
Pklr C57BL/6J Cryopreserved Sperms
Ppara C57BL/6N Cryopreserved Sperms
Prkaa1 C57BL/6N Cryopreserved Sperms
Prkaa2 C57BL/6N Cryopreserved Sperms
Prkab1 C57BL/6J Cryopreserved Sperms
Prkab2 C57BL/6J Cryopreserved Sperms
Prkag1 C57BL/6J Cryopreserved Sperms
Prkag2 C57BL/6N Cryopreserved Sperms
Prkag3 C57BL/6J Cryopreserved Sperms
Rac1 C57BL/6J Cryopreserved Sperms
Rela C57BL/6J Cryopreserved Sperms
Rxra C57BL/6J Cryopreserved Sperms
Sdha C57BL/6J Cryopreserved Sperms
Sdhb C57BL/6J Cryopreserved Sperms
Sdhc C57BL/6J Cryopreserved Sperms
Sdhd C57BL/6J Cryopreserved Sperms
Socs3 C57BL/6J Cryopreserved Sperms
Srebf1 C57BL/6J Cryopreserved Sperms
Tgfb1 C57BL/6J Cryopreserved Sperms
Tnf C57BL/6N Cryopreserved Sperms
Tnfrsf1a C57BL/6N Cryopreserved Sperms
Traf2 C57BL/6J Cryopreserved Sperms
Uqcr10 C57BL/6J Cryopreserved Sperms
Uqcr11 C57BL/6J Cryopreserved Sperms
Uqcrb C57BL/6J Cryopreserved Sperms
Uqcrc1 C57BL/6J Cryopreserved Sperms
Uqcrc2 C57BL/6J Cryopreserved Sperms
Uqcrfs1 C57BL/6J Cryopreserved Sperms
Uqcrh C57BL/6J Cryopreserved Sperms
Uqcrq C57BL/6J Cryopreserved Sperms
Xbp1 C57BL/6J Cryopreserved Sperms

 

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