Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model

Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model


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The diet-induced non-alcoholic fatty liver disease (NAFLD) model is established by feeding animals with high-fat and high-sugar diets, leading to overnutrition – the excessive amounts of lipids, cholesterol, and/or carbohydrates in the food cannot be fully absorbed and utilized. This overnutrition results in lipids accumulation, further inflammatory changes, and fibrosis. This model is the most commonly used NAFLD animal model for human NAFLD research. Different diet-induced models vary in characteristics, as shown below:

Model Mouse Type Obesity Insulin Resistance (IR) Dyslipidemia Elevated Transaminase Fatty Degeneration of Liver Hepatic Fibrosis
High-fat Diet Model Mouse Y Y Y Y Y -
Rat Y Y Y Y Y -
High-sugar Diet Model Mouse - Y Y N Y -
Rat Y Y Y N Y -
High-fat & High-sugar Diet Model Mouse Y Y Y Y Y Y
Rat Y Y Y Y Y Y
Methionine & Choline Deficient Diet Model Mouse N N N Y Y Y
Rat N N N Y Y Y

Note: Y: Yes, N: No, (-): without report

Detection Items: Body weight, food intake, serum biochemical test (alanine aminotransferase, aspartate aminotransferase, serum total cholesterol, triglyceride content, etc.), pathological analysis of liver tissue (liver tissue H & E staining, oil red).


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