NOD scid Mice

NOD scid Mice

 

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Genetic Background: NOD

Color: Albino

Coat Color Loci: Tyrc

Strain Description:

● The SCID mutation has been introduced onto a non-obese diabetic (NOD) mouse background

● Congenital T and B lymphocyte immunodeficiency.

● Due to the NOD background, the activity of natural killer (NK) cells is decreased.

● Does not develop diabetes.

Phenotype Information and Application:

● NOD SCID contain multiple unique immunodeficiencies which together provide an excellent system for the reconstruction of human hematopoietic cells, serving as an important model for HIV-1 (human immunodeficiency virus 1) research and gene therapy.

● An important tool for cancer research into increased incidence of tumors, especially for lymphomas and thymic tumors.

● Life span shortened to about 8-9 months, due to lethal thymic lymphomas

Health Standard: SPF