Cell Line-derived Tumor Xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice. After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to the long-term cell passage in vitro, they have the characteristics of high homology, easy construction, and reproducibility.
Typical Injection Sites: Subcutaneous, Intravenous, or in situ.
Cyagen Available Services with CDX models
Cyagen can develop custom CDX mouse models based on our customer’s requirements.
Cyagen CDX models include, but are not limited to, the following tumor types:
Breast cancer, liver cancer, bowel cancer, pancreatic cancer, lung cancer, stomach cancer, kidney cancer, prostate cancer, melanoma, bladder cancer, leukemia, ovarian cancer, brain cancer, and more.
|Cell Line Type||Cancer Type||Cell Line Detail|
|Mouse Cell Lines||Melanoma||B16, B16-F10CT26.WT, MC38|
|Human Cell Lines||Cervical||Hela|
We can also provide various pharmacological evaluation methods to meet customers' various needs for drug mechanism analysis – delivering reliable and expedient data reporting for your project.
● Tumor growth curve/weight curve
● Blood biochemical indicators
● Pathological tests: frozen section and paraffin section examination, H&E staining, immunohistochemistry (IHC), etc.
● Flow cytometry
● Molecular testing
● And More!
Selected Cell line Derived Xenografts (CDX) Model Case Study:
A549 Human non-small cell lung cancer (NSCLC) cell subcutaneous tumor model
A549 cells were inoculated into BALB/c nude mice, NOD/SCID mice, and BRGSF mice through subcutaneous injection, to measure the tumor volume at different time points. The growth curve of A549 Human non-small cell lung cancer cell subcutaneous tumor results is shown below.
Figure 1. Formation experiment of A549 Human non-small cell lung cancer (NSCLC) cell subcutaneous tumor.
Figure 2. Photos of nude mice inoculated with A459 cells 6 weeks after inoculation.
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